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RNAi: Differences and similarities between siRNA vs miRNA and RITS vs RISC (Concept map)
RNAi: Differences and similarities between siRNA vs miRNA and RITS vs RISC (Concept map)

RNAi: Differences and similarities between siRNA vs miRNA and RITS vs RISC (Concept map)

Map summary:

MicroRNAs are:

  1. Endogenous to our genome (conserved genes)
  2. act on many types of mRNA’s and possibly other RNA’s
  3. act primarily in plant and animal development

SiRNAs are:

  1. of viral origin
  2. only act on ONE type of mRNA

both are cut into a functional molecule via DICER protein

When said cuts are combined with other proteins to form a complex they are EITHER

  1. RITS: (RNA induced transcriptional silencing)
  2. RISC: (RNA induced silencing complex)

RITS acts to epigeneitcally modify chromatin

RISC acts to either block translation or degrade the mRNA

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